Endosim has a large group of experienced simulation staff ready to assist with your R&D needs. The use of a well-designed simulation setup allows repetitive testing of endoscopic and surgical instruments in a standardized and controlled setting. This allows the R&D team top obtain valuable answers about the functionality and durability of prototypes. Many questions can be answered in ex-vivo simulation models rather than using more expensive live animal models.
Examples of Feasibility & Efficacy Studies conducted with the support of Endosim R&D resources:
Lee SH, Gromski MA, Derevianko A, Jones DB, Pleskow DK, Sawhney M, Chuttani R, Matthes K. Efficacy of a Prototype Endoscope with Two Deflecting Working Channels for Endoscopic Submucosal Dissection: A Prospective Comparative Ex-vivo Study. Gastrointest Endosc. Gastrointest Endosc. 2010 Jul;72(1):155-60. Epub 2010 May 20.
Matthes K, Jung Y, Kato M, Gromski MA, Chuttani R. Efficacy of full-thickness GI perforation closure with a novel over-the-scope clip application device: an animal study. Gastrointest Endosc. 2011 Oct 7. Gastrointest Endosc. 2011 Dec;74(6):1369-75. Epub 2011 Oct 7.
Kato M, Jung Y, Gromski MA, Chuttani R, Matthes K. Prospective, randomized comparison of 3 different hemoclips for the treatment of acute upper GI hemorrhage in an established experimental setting. Gastrointest Endosc. 2012 Jan;75(1):3-10. Epub 2012 Jul 18.
Jung Y, Kato M, Lee J, Gromski M, Chuttani R, Matthes K. Effectiveness of circumferential endoscopic mucosal resection with a novel tissue-anchoring device. World J Gastrointest Endosc. 2013 Jun 16;5(6):275-80.
Jung Y, Kato M, Lee J, Gromski M, Chuttani R, Matthes K. Prospective, Randomized Comparison of a Prototype Endoscope with Deflecting Working Channels vs. a Conventional Double-Channel Endoscope for Rectal Endoscopic Submucosal Dissection in an Established Experimental Simulation Model (with Video). Gastrointest Endosc. 2013 Jun 5.
Gweon TG, Matthes K. Prospective, Randomized Ex Vivo Trial to Assess the Ideal Stapling Site for Endoscopic Fundoplication with Medigus Ultrasonic Surgical Endostapler. Gastroenterol Res Pract. 2016;2016:3161738.